Abstracts of the 8th Meeting of the Italian Peripheral Nerve Study Group: 7
| Autor: | B Nucciarone, D Borghetti, Gabriele Siciliano, P Maritato, G Moscato, R Calabrese, O Baglini, Ferdinando Sartucci |
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| Rok vydání: | 2003 |
| Předmět: |
medicine.medical_specialty
Weakness General Neuroscience medicine.disease Motor unit Physical medicine and rehabilitation Statistical significance Cohort Physical therapy medicine Motor unit number estimation Neurology (clinical) medicine.symptom Amyotrophic lateral sclerosis Psychology Pathological Wasting |
| Zdroj: | Journal of the Peripheral Nervous System. 8:29-58 |
| ISSN: | 1085-9489 |
| DOI: | 10.1046/j.1529-8027.2003.00007.x |
| Popis: | The pathological hallmark of amyotrophic lateral sclerosis (ALS) is the progressive death of upper and lower motor neurons, leading to a clinical pictures mainly characterized by weakness, muscle wasting, brisk reflexes and Babinski sign. Routine electromyographic and electroneurographic studies are mandatory to a correct diagnosis but are unable to precisely quantify the pathological changes in the motor unit. Motor unit number estimation (MUNE) is a recent neurophysiological technique that allows to estimate number and amplitude of motor units in single muscles in order to assess the severity of ALS and to follow-up the progression of the disease. We applied this technique in 15 patients (12 male and 3 female; mean age ± SD: 65.7 ± 9.5 yrs, range 45–82), affected by definite or probable ALS according to El Escorial Criteria, and in 11 healthy subjects (4 male and 7 female; mean age ± SD: 63.7 ± 8.2 yrs, range 50–76), in order to assess changes in motor unit features of abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. We found a significant difference (p |
| Databáze: | OpenAIRE |
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