ChemInform Abstract: Synthesis and Antitumor Activity of Hydrosoluble Analogs of p-(3,3-Dimethyl-1-triazeno)benzoic Acid Potassium Salt

Autor:	Lucia Lassiani, E. Boccù, L. Perissin, Antonio Varnavas, C. Nisi, Gianni Sava
Rok vydání:	2010
Předmět:	Antitumor activity chemistry.chemical_classification Potassium Potentiometric titration chemistry.chemical_element Lewis lung carcinoma Salt (chemistry) General Medicine Medicinal chemistry Cinnamic acid chemistry.chemical_compound chemistry Organic chemistry Triazene Benzoic acid
Zdroj:	ChemInform. 23
ISSN:	0931-7597
DOI:	10.1002/chin.199220129
Popis:	The hydrosoluble triazene derivatives of phenylacetic, phenylbutyric and cinnamic acid have been synthesized and their logP and pKa values were simultaneously determined according to a multiparametric fitting of potentiometric data. The antitumor activity caused by the synthesized compounds in mice bearing either Lewis lung carcinoma or TLX5 lymphoma was evaluated and discussed in comparison with the parent compound (p-(3,3-dimethyl-1-triazeno)benzoic acid potassium salt (DM-COOK, CAS 70055-49-1). The tested compounds were at least as active as DM-COOK, the cinnamic and the phenylacetic derivatives being the more active compounds in mice bearing TLX5 lymphoma and Lewis lung carcinoma, respectively.
Databáze:	OpenAIRE
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