Hydrodynamic blood plasma separation in microfluidic channels

Autor:	Marc P.Y. Desmulliez, Maïwenn Kersaudy-Kerhoas, R.S. Dhariwal, Lionel Jouvet
Rok vydání:	2009
Předmět:	Chromatography Chemistry Flow (psychology) Separation (aeronautics) Reynolds number Plasma Mechanics Condensed Matter Physics Electronic Optical and Magnetic Materials Volumetric flow rate symbols.namesake Microfluidic channel Blood plasma Materials Chemistry symbols Microscale chemistry
Zdroj:	Microfluidics and Nanofluidics. 8:105-114
ISSN:	1613-4990 1613-4982
DOI:	10.1007/s10404-009-0450-5
Popis:	The separation of red blood cells from plasma flowing in microchannels is possible by biophysical effects such as the Zweifach–Fung bifurcation law. In the present study, daughter channels are placed alongside a main channel such that cells and plasma are collected separately. The device is aimed to be a versatile but yet very simple module producing high-speed and high-efficiency plasma separation. The resulting lab-on-a-chip is manufactured using biocompatible materials. Purity efficiency is measured for mussel and human blood suspensions as different parameters, such as flow rate and geometries of the parent and daughter channels are varied. The issues of blood plasma separation at the microscale are discussed in relation to the different regimes of flow. Results are compared with those obtained by other researchers in the field of micro-separation of blood.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba8fdf4eb9de9b2c90e252136f54fd4f https://doi.org/10.1007/s10404-009-0450-5 Zobrazit plný text záznamu Full text from SpringerLink