Anti-Glomerular Basement Membrane Disease
| Autor: | F. Dammacco, Annamaria di Palma, Michele Rossini, Loreto Gesualdo, Vito Racanelli |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Autoimmune disease
Basement membrane Pathology medicine.medical_specialty business.industry Glomerular basement membrane medicine.medical_treatment Autoantibody Diffuse alveolar hemorrhage medicine.disease Anti-Glomerular Basement Membrane Disease Type IV collagen medicine.anatomical_structure medicine business Dialysis |
| Zdroj: | Systemic Vasculitides: Current Status and Perspectives ISBN: 9783319401348 |
| DOI: | 10.1007/978-3-319-40136-2_17 |
| Popis: | Anti-glomerular basement membrane disease is a severe autoimmune disease caused by autoantibodies against epitopes on alpha 3 chains of type IV collagen, found in the alveolar and glomerular basement membrane. It presents with renal failure often requiring dialysis and/or pulmonary symptoms due to alveolar hemorrhage that may be life threatening when massive. Diagnosis rely on recognition of anti-GBM antibodies at tissue level (often kidneys) and/or in the blood. Treatment is based on plasma exchange in order to remove autoantibodies from circulation and on immunosuppressive agents in order to reduce antibodies production. |
| Databáze: | OpenAIRE |
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