Ethyl Isocyanoacetate as a Useful Glycine Equivalent

Autor:	Somnath Halder, Sambasivarao Kotha
Rok vydání:	2010
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Alicyclic compound Suzuki reaction chemistry Stereochemistry Organic Chemistry Glycine Metathesis Amino acid Cyclophane
Zdroj:	Synlett. 2010:337-354
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0029-1219149
Popis:	In this account, we describe a useful synthetic approach to constructdiverse constrained α,α-dialkylated amino acidderivatives using ethyl isocyanoacetate as a glycine equivalent.Various unusual amino acid derivatives, such as cyclophane-, benzocyclo-butene-,and diene-containing systems, are reported here. 1 Introduction 2 Traditional Methods for the Synthesis of Cyclic α-Amino AcidDerivatives 2.1 Bucherer-Berg Method 2.2 Strecker Method 2.3 Schmidt Rearrangement Method 3 Glycine Equivalents 4 Preparation of Isocyanides 5 Preparation of Ethyl Isocyanoacetate 6 Synthesis of Cyclic Amino Acid Derivatives Using Various CarbonElectrophiles 7 Synthesis of Unusual Cyclophane-Based α-Amino Acid Derivatives 8 Synthesis of Bis-Armed Amino Acid Derivatives 9 Synthesis and Applications of Acyclic and Alicyclic Amino AcidDerivatives 10 Conclusion
Databáze:	OpenAIRE
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