New pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid esters are preferential M1, M3 muscarinic antagonists. Synthesis and bronchospasmolytic activity

Autor:	Ezhaya Antoine, Giovanbattista Schiavi, Angelo Sagrada, E. Bellora, Arturo Donetti, Henri Doods, Enzo Cereda
Rok vydání:	1994
Předmět:	Pharmacology Bicyclic molecule Stereochemistry Organic Chemistry Muscarinic acetylcholine receptor M3 Biological activity General Medicine Muscarinic acetylcholine receptor M1 In vitro chemistry.chemical_compound chemistry In vivo Drug Discovery Muscarinic acetylcholine receptor Lactam
Zdroj:	European Journal of Medicinal Chemistry. 29:411-421
ISSN:	0223-5234
DOI:	10.1016/0223-5234(94)90068-x
Popis:	A series of new 3-tropanol and 3-quinuclidinol esters of phenyl-substituted pyrrolidin-, piperidin- and azepin-2-oxocarboxylic acid were synthesized and tested for antimuscarinic activity. The compounds showed a preferential in vitro activity at M1 and M3 receptor subtypes and an interesting activity profile in vivo. A potential use as selective bronchospasmolytic agents has been suggested for selected compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba8113c1be1f84a9b725dcb07b6815c8 https://doi.org/10.1016/0223-5234(94)90068-x Zobrazit plný text záznamu