Effect of Triamterene on the Mammalian Distal Tubule in vivo

Autor:	F B Lacy, Dennis C. Dobyan, Rex L. Jamison
Rok vydání:	1979
Předmět:	Triamterene medicine.medical_specialty Renal sodium reabsorption Potassium Distal tubule chemistry.chemical_element General Medicine Endocrinology chemistry Nephrology In vivo Intragastric administration Internal medicine medicine Cardiology and Cardiovascular Medicine medicine.drug
Zdroj:	Kidney and Blood Pressure Research. 2:36-43
ISSN:	1423-0143 1420-4096
DOI:	10.1159/000172690
Popis:	Using the recollection micropuncture technique it was demonstrated that the intragastric administration of triamterene significantly reduced the fraction of filtered potassium remaining (from 27 to 17%) and enhanced the fraction of filtered sodium remaining (from 3.6 to 7.9%) at the end of the accessible distal tubule in 7 rats. Fractional delivery of water, sodium and potassium to the distal tubule was not significantly altered. Urinary potassium excretion was reduced (from 17 to 7%). Similar experiments in 6 control rats disclosed no significant changes in the foregoing variables. In these experiments the principal effect of triamterene in vivo was an inhibition of potassium secretion in the distal tubule. An ostensible inhibitory effect on sodium reabsorption in the distal tubule was not unequivocally established.
Databáze:	OpenAIRE
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