CPT1A Missense Mutation Associated With Fatty Acid Metabolism and Reduced Height in Greenlanders
| Autor: | Mikael Andersson, Line Skotte, Frank Geller, Michael L. Pedersen, Malene Børresen, Bjarke Feenstra, Anders Koch, Victor Yakimov, Jacqueline M. Mistry, Guy A. Rouleau, Sascha Wilk Michelsen, Johan Emdal Navne, Mads Melbye, Bolette Søborg, Patrick A. Dion, Sirui Zhou |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Genetics chemistry.chemical_classification education.field_of_study Fatty acid metabolism Population Fatty acid Locus (genetics) Genome-wide association study Biology 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology chemistry Missense mutation Allele Cardiology and Cardiovascular Medicine education Genetics (clinical) Polyunsaturated fatty acid |
| Zdroj: | Circulation: Cardiovascular Genetics. 10 |
| ISSN: | 1942-3268 1942-325X |
| DOI: | 10.1161/circgenetics.116.001618 |
| Popis: | Background— Inuit have lived for thousands of years in an extremely cold environment on a diet dominated by marine-derived fat. To investigate how this selective pressure has affected the genetic regulation of fatty acid metabolism, we assessed 233 serum metabolic phenotypes in a population-based sample of 1570 Greenlanders. Methods and Results— Using array-based and targeted genotyping, we found that rs80356779, a p.Pro479Leu variant in CPT1A , was strongly associated with markers of n -3 fatty acid metabolism, including degree of unsaturation ( P =1.16×10 − 34 ), levels of polyunsaturated fatty acids, n -3 fatty acids, and docosahexaoenic acid relative to total fatty acid levels ( P =2.35×10 − 15 , P =4.02×10 − 19 , and P =7.92×10 − 27 ). The derived allele (L479) occurred at a frequency of 76.2% in our sample while being absent in most other populations, and we found strong signatures of positive selection at the locus. Furthermore, we found that each copy of L479 reduced height by an average of 2.1 cm ( P =1.04×10 − 9 ). In exome sequencing data from a sister population, the Nunavik Inuit, we found no other likely causal candidate variant than rs80356779. Conclusion— Our study shows that a common CPT1A missense mutation is strongly associated with a range of metabolic phenotypes and reduced height in Greenlanders. These findings are important from a public health perspective and highlight the usefulness of complex trait genetic studies in isolated populations. |
| Databáze: | OpenAIRE |
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