A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

Autor:	Ryan J. Watts, Richard Mayeux, Timothy W. Behrens, Oded Foreman, Ward Ortmann, Gerard D. Schellenberg, Julie Hunkapiller, Lindsay A. Farrer, Susan M Sa, Robert R. Graham, Tushar Bhangale, Murat Yaylaoglu, Carlos Cruchaga, Jasvinder K. Atwal, Jonathan L. Haines, Nisha Rathore, Karpagam Srinivasan, Margaret A. Pericak-Vance, Marc Tessier-Lavigne, Janice A. Maloney, David V. Hansen, Alison Goate, Monica K Wetzel-Smith
Rok vydání:	2014
Předmět:	Programmed cell death Mutation HEK 293 cells Late onset General Medicine Disease Biology UNC5C medicine.disease medicine.disease_cause General Biochemistry Genetics and Molecular Biology Immunology medicine Alzheimer's disease
Zdroj:	Nature Medicine. 20:1452-1457
ISSN:	1546-170X 1078-8956
DOI:	10.1038/nm.3736
Popis:	Mutations in UNC5C are identified in individuals with late-onset Alzheimer's disease and increase susceptibility of neurons to cell death.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba6d1694b0f4fcc3b849cfaaf240338c https://doi.org/10.1038/nm.3736 Zobrazit plný text záznamu Plný text ve formátu PDF