The Protective Effect of N-Acetylcysteine and Honey Against Lungs Damage of Mice (Mus Musculus) After Cigarette Smoke Exposure: A Histological Study

Autor: Yudhie Djuhastidar Tando, Yuniasih Mulyani Jubeline Taihuttu, Parningotan Yosi Silalahi, Zwesty Anggreany Salhuteru
Rok vydání: 2022
Předmět:
Zdroj: Journal of Biomedicine and Translational Research. 8:106-111
ISSN: 2503-2178
DOI: 10.14710/jbtr.v8i3.13982
Popis: Background: Cigarette smoke is a source of free radicals that could cause lung damage. Honey and N-Acetylcysteine have antioxidant effects that could play a role in preventing lung damage.Objective: This study aims to compare the effects of honey and N-Acetylcysteine on lung histological features of mice (Mus musculus) after exposure to cigarette smoke.Methods: This research is an actual experimental study with post-test only control group design. There were 25 adult male mice selected and divided into four groups, i.e., the standard control group (not given exposure or treatment); the negative control group (received 0.2 mL of aqua bidest and exposure to cigarette smoke); the first treatment group (received 0.2 ml of honey and exposure to cigarette smoke); the second treatment group (received 0.2 mL of N-Acetylcysteine and exposure to cigarette smoke). The treatment was carried out every day for 21 days.Result: One way ANOVA statistical test showed significant differences between the experimental groups (p
Databáze: OpenAIRE