Tinea capitis treatment and management
| Autor: | Sharaf Albelihshi, Ahmad Alqadheb, Ali Alshafie, Mousa Ghazwani, Sultan Bakri, Saad Almugbel, Ali Alzahrani, Nareman Sulaiman Shamlan, Faisal Murayr, Mushari Alkhaldi |
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| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | International Journal Of Community Medicine And Public Health. 5:2600 |
| ISSN: | 2394-6040 2394-6032 |
| DOI: | 10.18203/2394-6040.ijcmph20182452 |
| Popis: | Griseofulvin has been the normal treatment for tinea capitis. However, newer antifungal agents, mainly terbinafine, are increasingly being used due to the short period of treatment and more reliable absorption rates. We pursued to compare the efficacy of oral terbinafine and oral griseofulvin in the treatment and management of tinea capitis. A systematic search of PubMed and the Cochrane Library was conducted up to July 2017 to recognize relevant trials. We also searched for additional trials included in published systematic reviews and bibliographies of all relevant studies comparing terbinafine and griseofulvin in the treatment and management of tinea capitis in immunocompetent patients. Five studies comprising 2035 subjects were included. There was no significant difference in efficacy between griseofulvin (mean duration of treatment 8 weeks, range 6-12 weeks) and terbinafine (mean duration of treatment 4 weeks, range 2-6 weeks); odds ratio=1.2 favoring terbinafine (95% confidence interval [CI]=0.79-1.9; p=0.4). Subgroup analysis revealed that terbinafine was more efficacious than griseofulvin in treating Trichophyton species (1.7; 95% CI=1.28-2.1; p |
| Databáze: | OpenAIRE |
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