TaqIB allele polymorphism of the dopamine receptor D2 gene in patients with endogenous psychoses

Autor:	I. V. Oleichik, Lilia I. Abramova, Vera Golimbet, Kaleda Vg, Nosikov Vv, Orlova Va, O. V. Ab, Aksenova Mg
Rok vydání:	2000
Předmět:	medicine.medical_specialty business.industry Biophysics Locus (genetics) Endogeny Human genetics Genotype frequency Endocrinology Structural Biology Dopamine receptor D2 Internal medicine Genotype medicine Allele business Gene
Zdroj:	Molecular Biology. 34:328-330
ISSN:	1608-3245 0026-8933
DOI:	10.1007/bf02759661
Popis:	The genotype at theTaqIB locus of the dopamine receptor D2 (DRD2) gene was established by PCR in 113 healthy donors and 340 patients with endogenous psychoses. The allele and genotype frequencies in patients with affective psychoses significantly differed from those in controls and in patients with schizophrenia. The proportion of B2/B2 homozygotes decreased with increasing contribution of the affective component to the clinical manifestation of schizo-affective and affective disorders. TheTaqIB polymorphism was assumed to play a role in mood aberrations in patients with mental disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba625941edd86f86abf763eef2737098 https://doi.org/10.1007/bf02759661 Zobrazit plný text záznamu Full text from SpringerLink