Synthesis and biological activities of novel pyridazine derivatives
| Autor: | S. G. Tiratsuyan, Tiruhi A. Gomktsyan, A. A. Hovhannisyan, Armen V. Karapetyan, A. P. Yengoyan |
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| Rok vydání: | 2016 |
| Předmět: |
0106 biological sciences
0301 basic medicine Lignan biology fungi food and beverages Plant physiology Biological activity Plant Science biology.organism_classification 01 natural sciences 03 medical and health sciences Transformation (genetics) chemistry.chemical_compound 030104 developmental biology Point of delivery chemistry Germination Botany biology.protein Phaseolus 010606 plant biology & botany Peroxidase |
| Zdroj: | Russian Journal of Plant Physiology. 63:656-662 |
| ISSN: | 1608-3407 1021-4437 |
| Popis: | A series of pyridazine derivatives was synthesized and some of them showed a growth stimulatory activity during preliminary screening. Their effects on germination, morphogenesis, peroxidase activity and lignan content were tested on common bean (Phaseolus vulgaris L.) plants. 2-[4-(6-ethoxy-pyridazin-3-ylsulfanyl)-6-ethylamino-[1,3,5]triazin-2-ylsulfanyl]-acetamide (C8) accelerated flowering and fruit production. In these plants, total lignan amount in the leaves correlated with the corresponding peroxidase activities. This compound can be recommended against the lodging of crops. Like IAA, 2-(6-ethoxy-pyridazin-3-yl)-isothiourea hydrochloride (C3) stimulated adventitious root growth with necrotic transformation of the bottom stem node. It promoted growth of leaves, the early reproductive development and pod formation. Preparations C3 and C8 can be recommended for the shortening of the juvenile time. In plants treated with each of these compounds, the highest content of lignans was recorded possibly relating to type I “non-host”—like plants resistance. 2-(6-chloro-pyridazin-3-yl)-isothiourea hydrochloride (C2) exerted a stimulatory effect on the growth of vegetative organs. |
| Databáze: | OpenAIRE |
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