Voltammetric Sensing System for the Detection of Cholesterol Based on the Ni-Bisurea-Pyrographite Composite
| Autor: | K. V. Derina, D. V. Ismailov, Alexander P. Ilyin, Elena Korotkova, Anastasia A. Lukina |
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| Rok vydání: | 2018 |
| Předmět: |
Materials science
Mechanical Engineering 010401 analytical chemistry Composite number 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Mechanics of Materials lipids (amino acids peptides and proteins) General Materials Science 0210 nano-technology Voltammetry Sensing system Nuclear chemistry |
| Zdroj: | Key Engineering Materials. 769:250-255 |
| ISSN: | 1662-9795 |
| DOI: | 10.4028/www.scientific.net/kem.769.250 |
| Popis: | Cholesterol plays a crucial role in the human body. High cholesterol level in blood is a marker of CVDs. Therefore, cholesterol determination techniques are necessary for clinical practice. Currently used cholesterol determination techniques involve enzymes or expensive and complicated equipment. Electrochemical techniques are widely spread in test-systems and sensors construction. Novel modification procedure for enzymeless cholesterol determination is suggested in this study. The electrochemical behavior of cholesterol on modified electrode was studied with the usage of cyclic and differential pulse voltammetry. Obtained concentration range is linear from 0.1 up to 100 mM a conditions close to physiological (pH=6.86) with a quantification limit of 0.01 mM. Besides, the electrode surface morphology and pH-effect were studied. The developed technique is promising for the rapid determination of total cholesterol in blood. |
| Databáze: | OpenAIRE |
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