| Autor: |
Yi Zang, Jianping Wang, Zengwei Luo, Lianghu Gu, Xiao-Nian Li, Chunmei Chen, Yuan Zhou, Xu-Wen Li, Yihua Gong, Hucheng Zhu, Weiguang Sun, Junjun Liu, Yonghui Zhang |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Organic Chemistry Frontiers. 6:3274-3281 |
| ISSN: |
2052-4129 |
| Popis: |
Three pairs of enantiomers (±)-canescones A–C (1–3), along with a pair of stereoisomers canescones D (4) and E (5), aromatic polyketide dimers bearing unprecedented 5/6/6/6/5 heterocyclic chemical architectures with a rare pentacyclic dihydrobenzo[1,4]dioxine core, were isolated from the fungus Penicillium canescens. Structure elucidation unambiguously suggests that 1 and 2 feature a new cyclopentanone ring A rather than a pyrrolidinone or furanone ring present in 3–5. All compounds were assayed for PTP1B inhibitory activity, and their hypothetical biosynthetic pathways were proposed. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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