On the Mechanism of the Positive Feedback Action of Estradiol on Luteinizing Hormone Secretion in the Rhesus Monkey1
| Autor: | Martin A. Connaughton, J. Hotchkiss, Tamás Ördög, Ming Dao Chen, Ernst Knobil, Jason R. Goldsmith |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Pituitary gland Luteinizing hormone secretion medicine.drug_class Endocrinology Diabetes and Metabolism media_common.quotation_subject Biochemistry (medical) Clinical Biochemistry Biology Gonadotropic cell Biochemistry Gonadotropin secretion Endocrinology medicine.anatomical_structure Estrogen Internal medicine medicine Gonadotropin Luteinizing hormone Menstrual cycle media_common |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 83:4047-4053 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.83.11.5230 |
| Popis: | In women and rhesus monkeys, both the negative and positive feedback actions of estradiol (E2) on gonadotropin secretion (inhibition followed by a surge) can be exerted directly at the level of the pituitary gland. We have tested the hypothesis that the positive feedback action of E2 represents but an“ escape” from its negative feedback inhibition of gonadotropin secretion consequent to a desensitization of the gonadotropes occasioned by sustained exposure to elevated concentrations of the steroid. We have attempted to replicate such a desensitization by blocking the negative feedback action of E2 by the administration of a potent estrogen receptor antagonist devoid of any agonistic properties (ZM 182,780) to rhesus monkeys in the midfollicular phase of the menstrual cycle (n = 14). The estrogen antagonist, administered at a dose that in separate experiments completely blocked both the negative and the positive feedback effect of exogenous E2 on pituitary LH secretion, failed to produce a surge-like incre... |
| Databáze: | OpenAIRE |
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