| Popis: |
Periodontitis describes a group of related inflammatory diseases resulting in the destruction of the tissues that support the tooth. This disease results from the growth of diverse microflora (especially anaerobes) in the periodontal pockets and releases various bacterial enzymes, toxins, and stimulation of the body’s immune response. Scaling and Root planning is the basic treatment modality for periodontitis. Mechanical treatment is limited by physical impediments and biochemical considerations. Antimicrobial agents may be used as an adjunct to overcome the limitations of mechanical therapy. Nonsurgical controlled intrapocket delivery of antimicrobials in the treatment of periodontitis has been investigated for the possibility of overcoming the limitations of conventional therapy. Nonsurgical controlled release formulations to deliver antibacterial to the site of periodontal pocket are designed to be of low cost, nontoxic, biocompatible, biodegradable, greater stability, non-immunogenicity, and effective long-term treatment at the site of infection with reduced systemic dosing. A number of polymer based delivery systems like fibers, strips, films, chips, microparticles, nanoparticles, and nanofiber made from a variety of natural and synthetic materials have been successfully tested to deliver a variety of drugs. Periodontal pockets as a drug delivery platform for designing a suitable dental localized dosage form along with its potential advantage and limitations is reviewed here. |
