The relationship between first-trimester haemoglobin a1c and pregnancy loss in women with type 1 diabetes mellitus

Autor:	Adrian Vlad, Viorel Șerban, Cristina Ilie, Bogdan Timar, Romulus Timar, Oana Sdic, Alin Albai
Rok vydání:	2012
Předmět:	Type 1 diabetes medicine.medical_specialty Pregnancy Obstetrics business.industry Adverse outcomes Haemoglobin A1c medicine.disease First trimester Diabetes mellitus Relative risk medicine business Glycemic
Zdroj:	Romanian Journal of Diabetes Nutrition and Metabolic Diseases. 19:229-236
ISSN:	2284-6417 2068-8245
DOI:	10.2478/v10255-012-0028-y
Popis:	Background and aims: A precarious glycemic control in the first 10 weeks ofpregnancy, the period defining organogenesis, increases the risk of pregnancy loss.The aim of this study was to estimate the relationship between pregnancy loss andHbA1c values in early pregnancy in type 1 diabetic women.Material and method: The present study included all pregnancies in type 1 diabetic women followed atDiabetes Clinic, Emergency County Clinical Hospital, Timişoara, from 1990-2011.Results: The risk of pregnancy loss was significantly increased compared with thebackground control group. In our study the relative risk of pregancy loss increasedwhen HbA1c exceeded 6.5%. We found a consistent increasing risk with stepwiseincreasing levels of HbA1c. Conclusions: A better glycemic control in this periodand throughout the pregnancy could reduce the risk of severe adverse outcomes intype 1 diabetic pregnancies.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba4055f2da68b91a617c65de8f4a89fd https://doi.org/10.2478/v10255-012-0028-y Zobrazit plný text záznamu