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of M99, 1 mg of the antagonist (approximately 11% of the recovery dose) was administered intramuscularly to try to increase the respiration rate. About 15 minutes later respiration was still around 1 breath/minute, and an additional 1 mg of M50-50 was given. Respiration improved visibly a few minutes after the 2nd injection. Six minutes later, the bear suddenly lifted its head, rose to a crouch, then lay back down with its head between its paws. As we approached the bear to administer additional M99, it suddenly arose and ran off. Use of M50-50 as a drug to combat M99-induced trauma, specifically respiration depression, is not recommended unless rapid and complete recovery is desired. Acknowledgments.-These data were collected during research funded by the U.S. Fish and Wildlife Service, National Fish and Wildlife Laboratory Polar Bear Project and cooperative grant USDI 1416-0008-1217 to D. B. Siniff, University of Minnesota. We thank J. R. Tester, University of Minnesota and pilots A. Browning and C. Wesson for their assistance in the field. |
