Impact of HBV genotype and mutations on HBV DNA and qHBsAg levels in patients with HBeAg-negative chronic HBV infection

Autor:	K.-H. Peiffer, Johannes Vermehren, Christoph Sarrazin, Bingfu Jiang, Alica Kubesch, Lisa Kuhnhenn, Fabian Finkelmeier, Stefan Zeuzem, Simone Susser, Julia Dietz, V Knop, Gert Carra, Eberhard Hildt, Georgios Grammatikos
Rok vydání:	2018
Předmět:	0301 basic medicine HBsAg Hepatology business.industry Gastroenterology virus diseases Promoter Disease Virology digestive system diseases 03 medical and health sciences Basal (phylogenetics) 030104 developmental biology 0302 clinical medicine Cell culture Genotype Hbv genotype Molecular virology Medicine 030211 gastroenterology & hepatology Pharmacology (medical) business
Zdroj:	Alimentary Pharmacology & Therapeutics. 47:1523-1535
ISSN:	0269-2813
Popis:	BACKGROUND HBV DNA and quantitative (q)HBsAg levels as prognostic markers for HBV-related disease are mostly validated in Asia and their significance in Western populations is uncertain. AIM To analyse the impact of the HBV genotype and frequent mutations in precore (PC), basal core promoter (BCP) and preS on HBV DNA and qHBsAg levels. METHODS HBV DNA and qHBsAg serum levels of 465 patients with HBeAg-negative chronic HBV infection were correlated with the HBV genotype and mutations in PC, BCP and preS. For a detailed analysis of the molecular virology, genotype A2 genomes harbouring these mutations were analysed for replication efficacy and HBsAg release in cell culture. RESULTS While no impact of the HBV genotype on HBV DNA levels was observed, qHBsAg levels differed up to 1.4 log among the genotypes (P
Databáze:	OpenAIRE
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