A gene expression microarray-based diagnostic test appplied to patients with carcinoma of unknown primary (CUP)
| Autor: | M. P. Goetz, W. D. Henner, Kevin C. Halling, C. T. Rigl, T. Kane Lindgren, M. J. Wilson, Fabiola Medeiros, C. P. Kolbert, F. Rakshan Rohakhtar |
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| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Journal of Clinical Oncology. 26:22123-22123 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.2008.26.15_suppl.22123 |
| Popis: | 22123 Background: The workup of tumors presenting as metastatic disease is often laborious and expensive; many malignancies remaining unclassified as to site of origin. A gene expression test has been validated as an identifier of tissue of origin using metastatic tumors in which the primary site is known (Monzon 2007, Dumur 2008). Agreement with pathologist-issued diagnoses was 89.5% (95% CI 86.4 - 92.1%, n = 477). The test is not cleared by the FDA and was not validated in patients with CUP. We sought to determine the diagnostic performance of this test using CUP specimens from the Mayo Clinic tissue bank. Methods: Eleven fresh-frozen tumor biopsies derived from patients with CUP were processed with the Pathwork® Tissue of Origin (TOO) Test (Pathwork Diagnostics, Sunnyvale, CA). The TOO Test uses expression signals from 1,550 probe sets to quantitatively measure the similarity of tumor specimens to 15 tissues of origin. Each patient previously underwent a full clinical and imaging workup; tissue specime... |
| Databáze: | OpenAIRE |
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