Mineralization of biomimetically carboxymethylated collagen fibrils in a model dual membrane diffusion system
| Autor: | Vasily V. Bazhenov, Thomas Henle, Dorin Geiger, Ralf Hoffmann, Christiane Fischer, René Born, Thomas Hanke, Hartmut Worch, Andrej Frolov, Uwe Schwarzenbolz, Paul Simon, Tobias Langrock, Hermann Ehrlich |
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| Rok vydání: | 2009 |
| Předmět: |
Membrane diffusion
Chemistry Diffusion Filtration and Separation macromolecular substances Glucuronic acid Biochemistry Mineralization (biology) Collagen fibril chemistry.chemical_compound Membrane Glycation Biophysics General Materials Science Physical and Theoretical Chemistry Octacalcium phosphate |
| Zdroj: | Journal of Membrane Science. 326:254-259 |
| ISSN: | 0376-7388 |
| DOI: | 10.1016/j.memsci.2008.10.003 |
| Popis: | In the present work, we show for the first time, that N ɛ -carboxymethyllysine is the major product of the in vitro non-enzymatic glycation reaction between fibrillar collagen and glucuronic acid . Dual diffusion membrane system was effectively used for oriented crystal growth of octacalcium phosphate/hydroxyapatite on the biomimetically carboxymethylated collagen fibrils. We hypothesize that the function of biomimetically carboxymethylated collagen is to increase the local concentration of corresponding ions in such a way that a critical nucleus of ions can be formed, leading to the formation of the mineral under specific micro-environment conditions achieved by using diffusion membrane system. |
| Databáze: | OpenAIRE |
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