Inhibition of Histone Deacetylases 4 and 5 Reduces Titin Proteolysis and Prevents Reduction of TTN Gene Expression in Atrophied Rat Soleus Muscle after Seven-Day Hindlimb Unloading

Autor:	T. L. Nemirovskaya, V. K. Zhalimov, Boris Shenkman, A. D. Ulanova, Yu. V. Gritsyna, Ivan M. Vikhlyantsev, S. S. Popova, A. G. Bobylev
Rok vydání:	2020
Předmět:	animal structures Proteolysis Biophysics Hindlimb Biochemistry 03 medical and health sciences Atrophy Gene expression medicine 030304 developmental biology Soleus muscle 0303 health sciences medicine.diagnostic_test biology Chemistry musculoskeletal neural and ocular physiology 030302 biochemistry & molecular biology Skeletal muscle General Chemistry General Medicine Hindlimb Suspension musculoskeletal system medicine.disease Cell biology medicine.anatomical_structure biology.protein Titin tissues
Zdroj:	Doklady Biochemistry and Biophysics. 495:338-341
ISSN:	1608-3091 1607-6729
Popis:	The effect of HDACs 4 and 5 on the level of atrophy, calpain-1 and titin content, and TTN gene expression in rat soleus after 7-day gravitational unloading (hindlimb suspension model) was studied. The development of atrophic changes induced by gravitational unloading in rat soleus was accompanied by an increase in the calpain-1 content, an increase in titin proteolysis, and a decrease in the mRNA content of the protein. Inhibition of HDACs 4 and 5 did not eliminate the development of unloading-induced atrophy but significantly prevented proteolysis of titin and the decrease in the TTN gene expression.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba18fe6474e88cedbac303ff6a92bbdf https://doi.org/10.1134/s1607672920060058 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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