| Autor: |
Olivier Loréal, L. Lauvin, Romain Moirand, Dominique Guyader, H. Jouanolle, Gérard Lescoat, Bruno Turlin, Yves Deugnier, Pierre Brissot |
| Rok vydání: |
1992 |
| Předmět: |
|
| Zdroj: |
Journal of Hepatology. 16:122-127 |
| ISSN: |
0168-8278 |
| DOI: |
10.1016/s0168-8278(05)80104-7 |
| Popis: |
A retrospective study of 127 patients with untreated homozygous genetic hemochromatosis (HGH) was conducted to evaluate the respective roles of iron overload and non-iron-related factors in the development of hepatic fibrosis in HGH. Twenty-seven percent of the patients had cirrhosis, 21% had liver fibrosis and 52% had no fibrosis (prefibrotic group). The mean value of liver iron concentration was increased significantly (p or = 500, 12 had liver fibrosis or cirrhosis, versus 48/134 with liver iron concentration < 500. Chronic alcoholic men exhibited hepatic fibrosis or cirrhosis more frequently than non-alcoholic men (p < 0.001). Non-alcoholic men had hepatic fibrosis or cirrhosis more often than non-alcoholic women (p < 0.05). Cirrhotic and fibrotic patients were significantly older than prefibrotic patients whilst a significant correlation between age and liver iron concentration was found in younger patients only. These results suggest that the iron overload threshold necessary to induce fibrosis is modulated by non-iron-related factors such as alcoholism, sex and age. The development of fibrosis in HGH with liver iron concentration < 500 mumol/g is frequent and must lead to a search for associated non-iron-related fibrogenic factors. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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