New Insights into the Regulation of mTOR Signaling via Ca2+-Binding Proteins

Autor:	Yuna Amemiya, Masatoshi Maki, Hideki Shibata, Terunao Takahara
Rok vydání:	2023
Předmět:	Inorganic Chemistry Organic Chemistry General Medicine Physical and Theoretical Chemistry Molecular Biology Spectroscopy Catalysis Computer Science Applications
Zdroj:	International Journal of Molecular Sciences. 24:3923
ISSN:	1422-0067
DOI:	10.3390/ijms24043923
Popis:	Environmental factors are important regulators of cell growth and proliferation. Mechanistic target of rapamycin (mTOR) is a central kinase that maintains cellular homeostasis in response to a variety of extracellular and intracellular inputs. Dysregulation of mTOR signaling is associated with many diseases, including diabetes and cancer. Calcium ion (Ca2+) is important as a second messenger in various biological processes, and its intracellular concentration is tightly regulated. Although the involvement of Ca2+ mobilization in mTOR signaling has been reported, the detailed molecular mechanisms by which mTOR signaling is regulated are not fully understood. The link between Ca2+ homeostasis and mTOR activation in pathological hypertrophy has heightened the importance in understanding Ca2+-regulated mTOR signaling as a key mechanism of mTOR regulation. In this review, we introduce recent findings on the molecular mechanisms of regulation of mTOR signaling by Ca2+-binding proteins, particularly calmodulin (CaM).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::ba0c4e4391e83540c22f27b88cc04f34 https://doi.org/10.3390/ijms24043923 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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