Evaluation of silymarin and berberine efficiencies in the self-emulsifying drug delivery systemin paracetamol-induced experimental toxic liver injury
| Autor: | A. G. Shlyahtun, A. V. Kolodko, I. V. Zverinsky, P. G. Telegin, A. V. Titko, N. V. Yankevich, I. P. Sutsko, I. N. Semenenya |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antioxidant Milk Thistle medicine.medical_treatment Extraction (chemistry) Ethyl acetate Glutathione Pharmacology Flavonolignans 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Berberine medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis Hepatocyte medicine |
| Zdroj: | Doklady of the National Academy of Sciences of Belarus. 64:713-722 |
| ISSN: | 2524-2431 1561-8323 |
| DOI: | 10.29235/1561-8323-2020-64-6-713-722 |
| Popis: | The hepatoprotective properties of the silymarin and the plant alkaloid berberine combinationin experimental paracetamol-inducedliver damage were studied. Silymarin was obtained from milk thistle seeds. The conditions for extraction of flavonolignans (silymarin) were optimized. 70 % ethyl alcohol, ethyl acetate and water were used as extractants. It was shown that the optimal conditions for the extraction of flavonolignans in order to obtain the maximum yield of flavonolignans were alcohol extraction in a Soxhlet apparatus. The experiment showed that the combined of silymarin and berberine was greater than their individual actions, which most effectively permitted stabilization of hepatocyte membranes and prevented altering their integrity in paracetamol-induced toxic liver damage. The self-emulsifying system with silymarin and berberine to a greater extent a significant extent prevented dystrophic changes in hepatocytes and necrosis in liver tissue, reduced hyperfermentemia in rat blood serum, prevented disturbance in the activity of thioredoxin reductase and enzymes of the glutathione antioxidant system and there by more effectively prevented hepatocyte functional impairment. |
| Databáze: | OpenAIRE |
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