ZnCl2-Promoted One-Pot Three-Component Synthesis of Multisubstituted Thiazolo[4,5-b]pyridines and Thieno[2,3-b:4,5-b′]dipyridines

Autor:	Zemei Ge, Lanlan Meng, Runtao Li, Yongning Xing, Qi Sun, Yangqiu Peng, Laichun Luo
Rok vydání:	2014
Předmět:	Tandem Component (thermodynamics) Chemistry Organic Chemistry SN2 reaction Organic chemistry Physical and Theoretical Chemistry Alkylation
Zdroj:	European Journal of Organic Chemistry. 2015:631-637
ISSN:	1434-193X
DOI:	10.1002/ejoc.201403156
Popis:	A ZnCl2-promoted one-pot synthesis of multisubstituted thiazolo[4,5-b]pyridines and thieno[2,3-b:4,5-b′]dipyridines from mercaptonitrile salts, α-bromo ketones and ketones has been developed. This approach involves a tandem SN2 alkylation/Thorpe–Ziegler cyclization/Friedlander reaction, which allows the creation of two hetero rings and four new bonds in a single operation. The reaction proceeds smoothly under solvent-free conditions to afford fused pyridines in moderate to good yields.
Databáze:	OpenAIRE
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