| Autor: |
Martin Grootveld, Declan P. Naughton, Alexandra Furst, David R. Blake, Andrew W.D. Claxson, Michael J. Whelan |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Drugs in Inflammation ISBN: 9783034874076 |
| Popis: |
The effect of aurothiomalate on the status of a wide range of low-molecular-mass endogenous metabolites in blood plasma obtained from animals treated with an intravenous dose of this second-line agent (150 mg/kg) has been assessed by high field proton Hahn spin-echo NMR spectroscopy. As well as modulating the effective concentrations of NMR-detectable biomolecules, aurothiomalate induces a time-dependent decrease in plasma levels of triacylglycerols with a corresponding elevation in the concentration of the ketone body 3-D-hydroxybutyrate, indicating an increased utilisation of fats for energy in rats treated with this 1:1 gold(I)-thiolate complex. These observations may reflect the toxic side-effects that are associated with aurothiomalate treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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