Studies on chemical modification of monensin VIII. Synthesis of 7-O-substituted-25-carboxymonensins and their Ca2+ ion transport activity

Autor:	Akito Nagatsu, Jinsaku Sakakibara, Yukio Ogihara, Hajime Mizukami, Rie Tanaka
Rok vydání:	2001
Předmět:	Chemistry Organic Chemistry Monensin Inorganic chemistry Ionophore Chemical modification Biochemistry Ion chemistry.chemical_compound Membrane Drug Discovery Polymer chemistry Molecule Ion transporter
Zdroj:	Tetrahedron. 57:3005-3012
ISSN:	0040-4020
DOI:	10.1016/s0040-4020(01)00154-5
Popis:	Monensin (1), an ionophore antibiotic agent, was converted to 25-carboxymonensin (2) and 7-O-substituted-25-carboxyl derivatives (3a–d), which have two carboxyl groups at both ends of the molecule. Ca2+ ion transport activity of the dicarboxylic monensins was evaluated by the CHCl3 liquid membrane method, and 25-carboxymonensins (2 and 3a–d) were shown to transport the Ca2+ ion through the CHCl3 liquid membrane.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b9e8ebefd2f6e840aa993757e52226b8 https://doi.org/10.1016/s0040-4020(01)00154-5 Zobrazit plný text záznamu Full Text from ScienceDirect