Particle-induced Phagocytic Cell Responses are Material Dependent: Foreign Body Giant CellsVs.Osteoclasts from a Chick Chorioallantoic Membrane Particle-implantation Model
| Autor: | J. R. Wright, L. C. Carter, Robert E. Baier, P. A. Nickerson, J. M. Carter |
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| Rok vydání: | 2000 |
| Předmět: |
musculoskeletal diseases
Foreign-body giant cell Materials science Biomaterial Surfaces and Interfaces General Chemistry Surfaces Coatings and Films Chorioallantoic membrane medicine.anatomical_structure Mechanics of Materials Giant cell Osteoclast Materials Chemistry medicine Macrophage Implant Phagocytic Cell Biomedical engineering |
| Zdroj: | The Journal of Adhesion. 74:53-77 |
| ISSN: | 1545-5823 0021-8464 |
| Popis: | There is increasing concern about particles generated from wear-prone implants that are placed in body tissues, including artificial hip, knee, and jaw joints. Although phagocytes and foreign body giant cells are associated with inhaled or embedded particulate debris, some particles also induce bone digestion by eliciting the differentiation and proliferation of highly specialized osteoclastic cells. This report describes the differential phagocytic cellular responses to four implant-related types of ground, model wear particles in a live-egg cell-response model, as implants to the chick chorioallantoic membrane (CAM): polymethylmethacrylate (PMMA), a main constituent of some temporomandibular joint (TMJ) implants and orthopedic cements used to retain artificial hips and knees; Proplast-HA, an implantable composite of polytetrafluoroethylene (PTFE) and degradable mineral (hydroxyapatite) that has been associated with bone erosion around failed TMJ implants; talc, a nondegradable mineral sometimes... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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