Evaluation of the Ethnomedical Claims ofMurraya koenigii
| Autor: | Dieter Bergenthal, N. O. Omisore, S. Kolawole Adesina, Vijaya Kumar, Gbola Olayiwola, Ezekiel Olugbenga Iwalewa, J. Eugen Verspohl, AC Adebajo |
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| Rok vydání: | 2005 |
| Předmět: |
Pharmacology
Murraya biology Traditional medicine Cns depression Alkaloid Trichomonas medicine.drug_physiologic_effect Pharmaceutical Science Brine shrimp General Medicine Pharmacognosy biology.organism_classification Complementary and alternative medicine Drug Discovery medicine Molecular Medicine Bioassay IC50 |
| Zdroj: | Pharmaceutical Biology. 42:610-620 |
| ISSN: | 1744-5116 1388-0209 |
| DOI: | 10.1080/13880200490902518 |
| Popis: | Based on sethnomedicine, Murraya koenigii. (L.) Spreng. is used as a stimulant, antidysentery, and for the management of diabetes mellitus. Twelve carbazole alkaloids were isolated from the stem, seed, and leaf of the plant growing in Nigeria and Sri Lanka. The methanol extracts were devoid of hypoglycemic activity, and some isolates decreased insulin secretion when they were subjected to both in vivo. and in vitro. (insulin secretion from INS-1 cells) antidiabetic tests. The cytotoxicity of the leaf and stem methanol extracts determined by the brine shrimp lethality bioassay were LC50 61.5 and 14.5 µg/ml, respectively. These extracts caused CNS depression in albino mice at the dose levels of 25–400 mg/kg. Also, they had an IC50 of 34.0 and 35.0 µg/ml at 24 h, respectively, against trichomonas. These results confirmed the use of the plant as an antidysentery caused by trichomonas but refute the antidiabetic and stimulant ethnomedical claims for the plant. The differences observed in their alkaloid... |
| Databáze: | OpenAIRE |
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