Fast heavy-ion radiation damage of glycine in aqueous solution
| Autor: | Shinji Nomura, Ryosuke Furuya, Takuya Majima, Hidetsugu Tsuchida, Akio Itoh |
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| Rok vydání: | 2016 |
| Předmět: |
Nuclear and High Energy Physics
Aqueous solution Chemistry Inorganic chemistry Bragg peak 02 engineering and technology 021001 nanoscience & nanotechnology 01 natural sciences Dissociation (chemistry) Ion 0103 physical sciences Radiolysis Water environment Radiation damage Irradiation 010306 general physics 0210 nano-technology Instrumentation |
| Zdroj: | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. :28-32 |
| ISSN: | 0168-583X |
| DOI: | 10.1016/j.nimb.2016.11.019 |
| Popis: | Fast heavy-ion radiolysis of biomolecules in aqueous solution is investigated for an atomistic understanding of radiation damage to normal cells during heavy-particle beam therapy. The smallest amino acid glycine was used as a model biomaterial. Microjets of aqueous glycine solutions under vacuum were irradiated with 4.0-MeV carbon ions corresponding to energies in the Bragg peak region. To understand the effects of the water environment on molecular damage, the yield of glycine dissociation was measured by secondary ion mass spectroscopy. The yield was significantly reduced relative to gas-phase glycine targets. This implies that the numerous water molecules surrounding a single glycine molecule act as a buffer that suppresses dissociation. This is an environmental effect similar to that observed for other biomolecular cluster targets. |
| Databáze: | OpenAIRE |
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