Association between congenital heart disease and NKX2.5 gene polymorphisms: systematic review and meta-analysis

Autor:	María Lilia López-Narváez, Ruben Blachman-Braun, Juan Calderón-Colmenero, Nonanzit Pérez-Hernández, Carlos Alfonso Tovilla-Zárate, Isela Esther Juárez-Rojop, Rosalinda Posadas-Sánchez, Verónica Marusa Borgonio-Cuadra, Gilberto Vargas-Alarcón, Thelma Beatriz González-Castro, Rosa Giannina Castillo-Avila, Esbeidy García-Flores, José Antonio García-Montes, Benny Giovanni Cazarín-Santos, José Manuel Rodríguez-Pérez, Juan Pablo Sandoval
Rok vydání:	2020
Předmět:	education.field_of_study medicine.medical_specialty Heart disease business.industry Biochemistry (medical) Clinical Biochemistry Population medicine.disease Nkx2 5 gene Meta-analysis Internal medicine Drug Discovery Odd ratio Medicine Allele business education Association (psychology) Gene
Zdroj:	Biomarkers in Medicine. 14:1747-1757
ISSN:	1752-0371 1752-0363
Popis:	Aim: To analyze the association of NKX2.5 gene with congenital heart disease (CHD), and to determine if the variants rs703752, rs3729753 and rs2277923 increase the risk for developing CHD. Materials & methods: PubMed, EBSCO and Web of Science databases were screened to identify eligible studies. Through a comprehensive meta-analysis software, the association between NKX2.5 gene variants and susceptibility of CHD was calculated by pooled odd ratio (ORs) and 95% CI. Results: We observed that the allelic model of rs703752 and rs2277923 increased the risk in the overall population: OR = 1.24; 95% CI: 1.00–1.55; Z p-value = 0.049; OR = 1.18; 95% CI: 0.01–1.37; Z p-value = 0.036; respectively. Conclusion: Our results suggested that the rs703752 and rs2277923 polymorphisms of the NKX2.5 gene are associated with CHD.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b9bfad93be2b6fe6d9b5091526bb2778 https://doi.org/10.2217/bmm-2020-0190 Zobrazit plný text záznamu