Discovery and structure-activity studies of a novel series of pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors
| Autor: | Wayne D. Klohs, James Marino Hamby, Alan J. Kraker, David W. Fry, Cindy Shen, Aneesa Amar, Robert L. Panek, Gina H. Lu, Barvian Mark Robert, Connolly Cleo, Mel C. Schroeder, Annette Marian Doherty |
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| Rok vydání: | 1997 |
| Předmět: |
Platelet-derived growth factor
biology Pyrimidine Organic Chemistry Clinical Biochemistry Pharmaceutical Science Biochemistry chemistry.chemical_compound chemistry Fibroblast growth factor receptor Enzyme inhibitor Drug Discovery biology.protein Molecular Medicine Signal transduction Tyrosine Molecular Biology Tyrosine kinase Platelet-derived growth factor receptor |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 7:2415-2420 |
| ISSN: | 0960-894X |
| Popis: | The inhibition of tyrosine kinase-mediated signal transduction pathways represents a therapeutic approach to the intervention of proliferative diseases such as cancer, atherosclerosis, and restenosis. A novel series of pyrido[2,3-d]pyrimidine inhibitors of the PDGFr, bFGFr, and c-Src tyrosine kinases was developed from compound library screening and lead optimization.1 In addition, highly selective inhibitors of the FGFr tyrosine kinase were also discovered and developed from this novel series of pyrido[2,3-d]pyrimidines. The syntheses, biological evaluation, and structure-activity relationships of this series are reported. |
| Databáze: | OpenAIRE |
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