The Effect of Coenzyme Q10 on Blood Ascorbic Acid, Vitamin E, and Lipid Peroxide in Chronic Cadmium Intoxication
| Autor: | V.M. Petrović, Zikić Rv, Branka I. Ognjanović, Andraš Š. Štajn, Sladjan Z. Pavlović, Zorica S. Saičić |
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| Rok vydání: | 2001 |
| Předmět: |
inorganic chemicals
Coenzyme Q10 Cadmium medicine.medical_specialty Antioxidant Lipid peroxide Health Toxicology and Mutagenesis medicine.medical_treatment Vitamin E Decreased Concentration chemistry.chemical_element General Medicine Toxicology Ascorbic acid Pathology and Forensic Medicine chemistry.chemical_compound Endocrinology chemistry Biochemistry Internal medicine Toxicity medicine |
| Zdroj: | Journal of Environmental Pathology, Toxicology and Oncology. 20:8 |
| ISSN: | 0731-8898 |
| Popis: | The aim of our study was to investigate the possible protective role of coenzyme Q10 (CoQ10) administration on ascorbic acid (AsA), vitamin E (vit E), and lipid peroxide (LP) concentrations in the blood of rats chronically treated with cadmium. Results were compared to those obtained in control animals, as well as to those obtained in animals treated with olive oil. Compared to that of the control animals, the AsA concentration was significantly increased in rats treated with CoQ10 and olive oil, whereas vit E concentration was significantly increased in animals treated with cadmium, CoQ10, or cadmium + CoQ10. A significant decrease in LP concentration was noted in animals treated with cadmium or with cadmium + CoQ10o, whereas a significant increase was seen in animals treated with olive oil. Compared to that of the animals treated with olive oil, the ascorbic acid concentration was significantly decreased in rats treated with cadmium or with cadmium + CoQ10, whereas vit E concentration was significantly increased in animals treated with cadmium, CoQ10, or cadmium + CoQ10. LP concentration was significantly decreased in rats treated with cadmium, CoQ10, or cadmium + CoQ10. Our study showed that CoQ10 administration in rats chronically exposed to exogenous cadmium exerts beneficial effects on the nonenzymatic components of the antioxidant defense system, such as AsA and vit E, resulting in a decreased concentration of LP in the blood. |
| Databáze: | OpenAIRE |
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