Furans to Benzofurans: Intramolecular Cross-Benzoin Reactions Catalysed by N-Heterocyclic Carbenes
| Autor: | Rajendra P. Shirke, Virsinha Reddy, R. Vijaya Anand, S. S. V. Ramasastry |
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| Rok vydání: | 2016 |
| Předmět: |
Annulation
010405 organic chemistry Organic Chemistry chemistry.chemical_element 010402 general chemistry Condensation reaction 01 natural sciences Chloride Catalysis 0104 chemical sciences Bismuth chemistry.chemical_compound chemistry Benzoin Organocatalysis Intramolecular force medicine Organic chemistry Benzoin condensation medicine.drug |
| Zdroj: | Synthesis. 48:1865-1871 |
| ISSN: | 1437-210X 0039-7881 |
| Popis: | The first synthesis of dihydrobenzofuranones and benzofurans based on an intramolecular cross-benzoin reaction has been reported. Commercially available 3-furan carboxaldehydes are readily α-alkylated to furnish 3-formyl-2-furylcarbinols, which are further elaborated to the synthesis of benzofurans in good yields through sequential bismuth(III) chloride catalysed furfurylation and a novel NHC-promoted intramolecular cross-benzoin condensation reaction. |
| Databáze: | OpenAIRE |
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