Long-Term Dual Blockade With Candesartan and Lisinopril in Hypertensive Patients With Diabetes
| Autor: | Carl Erik Mogensen, Steen Hvitfeldt Poulsen, Niels Holmark Andersen, Per Løgstrup Poulsen, Søren Tang Knudsen, Kjeld Helleberg, Klavs Würgler Hansen, Hans Eiskjær |
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| Rok vydání: | 2005 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty business.industry Endocrinology Diabetes and Metabolism Lisinopril medicine.disease Dual blockade law.invention Candesartan Pharmacotherapy Endocrinology Blood pressure Randomized controlled trial law Diabetes mellitus Internal medicine Ambulatory Internal Medicine medicine Cardiology business circulatory and respiratory physiology medicine.drug |
| Zdroj: | Diabetes Care. 28:273-277 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.28.2.273 |
| Popis: | OBJECTIVE—To assess and compare the long-term effects of the combination of candesartan and lisinopril with high-dose lisinopril on systolic blood pressure in patients with hypertension and diabetes. RESEARCH DESIGN AND METHODS—This was a prospective, randomized, parallel-group, double-blind, double-dummy study with a 12-month follow-up. Drug therapy was either lisinopril 40 mg once daily or dual-blockade treatment with candesartan 16 mg once daily and lisinopril 20 mg once daily. The study comprised 75 type 1 and type 2 diabetic patients aged 35–74 years. The main outcome measures were seated and 24-h ambulatory systolic blood pressure. RESULTS—Reduction in systolic blood pressure (24-h systolic blood pressure) reduction was obtained in both treatment arms (mean reduction at final follow-up: dual blockade 6 mmHg vs. lisinopril 2 mmHg), but no significant difference was found between dual-blockade and lisinopril 40 mg once daily (P = 0.10). Both treatments were generally well tolerated, and similar low rates of side effects were found in the two groups. CONCLUSIONS—There was no statistically significant difference between lisinopril 40 mg once daily and lisinopril 20 mg in combination with candesartan 16 mg once daily in reducing systolic blood pressure in hypertensive patients with diabetes. |
| Databáze: | OpenAIRE |
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