Synthesis, photophysical, antibacterial and larvicidal studies on triazolophanes with 5-nitro isophthalate functionality at the intraannular position
| Autor: | Manisha Choudhury, Sivasamy Selvarani, S. Nagaraj, Perumal Rajakumar, Devadasan Velmurugan |
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| Rok vydání: | 2018 |
| Předmět: |
biology
010405 organic chemistry Chemistry General Chemistry Bacillus subtilis 010402 general chemistry medicine.disease_cause biology.organism_classification 01 natural sciences Combinatorial chemistry Catalysis Cycloaddition 0104 chemical sciences Materials Chemistry medicine Nitro Antibacterial activity Escherichia coli Target binding |
| Zdroj: | New Journal of Chemistry. 42:12684-12691 |
| ISSN: | 1369-9261 1144-0546 |
| DOI: | 10.1039/c8nj01248b |
| Popis: | 1 : 1 and 2 : 2 oligomeric triazolophanes with 5-nitro isophthalate and triazolyl functionalities at the intraannular position have been synthesized by copper(I) catalyzed 1,3 dipolar cycloaddition of the corresponding propargylic esters with various phenyl substituted aliphatic azides under mild conditions through click methodology. The 1 : 1 oligomeric triazolophanes exhibit good target binding ability and better antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Salmonella typhi and Escherichia coli bacteria than the 2 : 2 oligomeric triazolophanes, supported by molecular docking studies, and triazolophanes T3, T4 and T5 show good larvicidal activity. |
| Databáze: | OpenAIRE |
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