Hydroxypropyl Methylcellulose as a Novel Tool for Isothermal Solution Crystallization of Micronized Paracetamol

Autor:	Nuno M. Reis, Zizheng K. Liu, Malcolm R. Mackley, Cassilda M. Reis
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Materials science Economies of agglomeration Nucleation General Chemistry Polymer Condensed Matter Physics Isothermal process law.invention Crystal Crystallography Adsorption Chemical engineering chemistry law General Materials Science Crystallization Macromolecule
Zdroj:	Crystal Growth & Design. 14:3191-3198
ISSN:	1528-7505 1528-7483
DOI:	10.1021/cg4009637
Popis:	Pulmonary inhalation is increasingly being selected as a preferred route for the delivery of both small and large drug macromolecules for the treatment of a range of pathologies. The direct crystallization of micronized powders, in particular, paracetamol, remains difficult, as it requires the ability to work in high solution supersaturations where agglomeration, wall crusting, and heterogeneous nucleation hinder the control of crystal size and crystal size distribution. Polymer additives are recognized to help drive the production of a given polymorph or controlling crystal shape by means of adsorption on the crystal surface. With the aim of exploiting the polymer-control nucleation and growth of crystals for enhanced direct crystallization of micronized powders, batch cooling crystallization of paracetamol in water was carried out in the presence of 0.1–0.8% w/w hydroxypropyl methylcellulose (HPMC). In the presence of polymer, the onset of nucleation was delayed and extended beyond the cooling time of t...
Databáze:	OpenAIRE
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