Effective Immunity to Dental Caries: Protection of Gnotobiotic Rats by Local Immunization with Streptococcus Mutans

Autor:	Jerry R. McGhee, Suzanne M. Michalek, Jerry Webb, Juan M. Navia, A. F. R. Rahman, Donald W. Legler
Rok vydání:	1975
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 114:300-305
ISSN:	1550-6606 0022-1767
DOI:	10.4049/jimmunol.114.1_part_2.300
Popis:	Gnotobiotic rats injected in the submandibular region with killed, whole Streptococcus mutans cells developed salivary antibodies directed to this microorganism. Increased levels of salivary IgA and inhibition and augmentation of agglutinin titers with anti-rat α-antiglobulin suggested that these antibodies were of the immunoglobulin A class. Furthermore, the rats monoinfected and immunized with homologous organisms always had lower mean caries scores than monoinfected, non-immunized rats. This reduction was evident in carious lesions on the buccal surfaces of molars and in those in sulcal areas. These results suggest that local immunization with whole S. mutans cells stimulates a specific salivary IgA response protective against caries resulting from S. mutans infection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b983e04d7d3381e65042a76603b56054 https://doi.org/10.4049/jimmunol.114.1_part_2.300 Zobrazit plný text záznamu