The search for mRNA biomarkers: global quantification of transcriptional and translational responses to ionising radiation
| Autor: | S K Schreyer, J Albanese, N Dainiak |
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| Rok vydání: | 2005 |
| Předmět: | |
| Zdroj: | The British Journal of Radiology. :114-122 |
| ISSN: | 1748-880X 0007-1285 |
| DOI: | 10.1259/bjr/29577159 |
| Popis: | Since the discovery of X-rays and the subsequent realisation that ionising radiation (IR) can provide a curative mode of therapy to treat tumours, there has been a concerted effort to discover the mechanisms by which IR induces cells to die or to become resistant to radiotherapy. Classical genetic analyses and biochemical techniques have been used to identify an ever-expanding number of genes whose activation directly or indirectly influences DNA repair, cell cycle progression and apoptosis. The advent of cDNA microarrays provides an opportunity to explore further the biological processes fundamental to the radiation response by permitting a comprehensive assessment of a cell's transcriptional landscape. The capacity to study the expression patterns of thousands of genes simultaneously may lead to (i) an increased understanding of how IR-responsive genes from seemingly mutually exclusive pathways (i.e. DNA repair and apoptosis) interact to determine the fate of irradiated cells and (ii) the discovery of n... |
| Databáze: | OpenAIRE |
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