NIPSNAP1 deficient mice exhibit altered liver amino acid, lipid and nucleotide metabolism
| Autor: | Sarani Ghoshal, Lynn A Jones, Ramin Homayouni |
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| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Kidney Endocrinology Diabetes and Metabolism Clinical Biochemistry Phosphatase Metabolism Glutathione Mitochondrion Biology medicine.disease_cause Biochemistry Molecular biology Amino acid chemistry.chemical_compound medicine.anatomical_structure chemistry medicine Nucleotide Oxidative stress |
| Zdroj: | Metabolomics. 10:250-258 |
| ISSN: | 1573-3890 1573-3882 |
| DOI: | 10.1007/s11306-013-0583-0 |
| Popis: | 4-Nitrophenyl phosphatase domain and non-neuronal SNAP25-like protein homolog1 (NIPSNAP1) is an evolutionarily conserved protein found in a variety of species ranging from C. elegans to human. NIPSNAP1 protein is localized in mitochondria and is highly expressed in liver, brain and kidney. The molecular and cellular roles of NIPSNAP1 are still unknown. To gain insights into the function of NIPSNAP1, we generated a mouse model with a disruption of Nipsnap1 gene and performed metabolomic analysis on their liver tissues. Liver samples from 13 to 15 month old NIPSNAP1 deficient (n = 7) and wild-type (n = 8) mice were extracted and processed for analysis using liquid/gas chromatography followed by mass spectrometry (LC/MS and GC/MS). We examined a total of 291 compounds in liver samples and found 45 compounds whose levels were significantly altered (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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