| Autor: |
Choy, Cecilia, Khairul Ansari, Neman, Josh, Hsu, Sarah, Duenas, Matthew, Li, Hubert, Nagarajan Vaidehi, Jandial, Rahul |
| Rok vydání: |
2017 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.c.3756959_d2 |
| Popis: |
Expression of TrkB in various cells and tissue. Figure S2. Analysis of TrkB knockdown with two different TrkB shRNAs in patient-derived MDA-MB-361 cells (361-KD and 361-KD2). Figure S3. Western blot analysis of protein extracts from patient-derived 361 cells and 361 cells transduced with TrkB shRNA-1 (361-KD) or TrkB shRNA-2 (361-KD2) and cultured with BDNF. Figure S4. Real-time PCR quantification of BDNF expression in different metastasis sites. Figure S5. Western blot analysis of intracellular BDNF in BBM1 cells, 361 cells, astrocytes, and fibroblasts and proliferation of 361 cells and TrkB-specific shRNA1 (361-KD) and shRNA2 (361-KD2) transduced cells grown in astrocyte or fibroblast conditioned medium (CM). Figure S6. TrkB knockdown disrupts the metastatic efficiency of BBM2 xenografts. Figure S7. TrkB knockdown disrupts colonization and metastatic efficiency in BBM xenografts. Figure S8. TrkB and Her2 are co-expressed in BBM and breast cancer cells. Figure S9. Immunocytochemical staining of BBM1 and TrkB knockdown (BBM1-KD) cells treated with BDNF over different times. (PDF 1352 kb) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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