Frequency of circulating CD14 ++ CD16 + intermediate monocytes as potential biomarker for the diagnosis of oral squamous cell carcinoma
| Autor: | Qingang Hu, Yanhong Ni, Yue Jing, Xiaofeng Huang, Huidong Zhu, Yan Yang, Qian Zhou, Yuxian Song, Xiaoxin Zhang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.diagnostic_test Receiver operating characteristic business.industry CD14 Cancer CD16 medicine.disease Pathology and Forensic Medicine Flow cytometry stomatognathic diseases 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Otorhinolaryngology 030220 oncology & carcinogenesis Potential biomarkers Cancer research Periodontics Medicine Biomarker (medicine) Basal cell Oral Surgery business |
| Zdroj: | Journal of Oral Pathology & Medicine. 47:923-929 |
| ISSN: | 1600-0714 0904-2512 |
| Popis: | BACKGROUND Monocytes, which subdivided into three functional subsets (classical, intermediate, and nonclassical), play important roles in the progression of cancer. The subset composition is altered in several pathologic conditions including cancers. However, the composition and function of circulating monocyte subsets in patients with oral squamous cell carcinoma (OSCC) are still obscure. METHODS The frequencies of monocyte subsets in peripheral blood of patients with OSCC and healthy donors are determined by flow cytometry, and their diagnostic values for OSCC were evaluated. The associations between levels of monocyte subsets and clinicopathological features of patients with OSCC were analyzed using cross-tabulation with the chi-square test. RESULTS We demonstrated that the frequency of CD14++ CD16+ intermediate monocytes was remarkably increased (P 0.05). The receiver operating characteristic (ROC) curve analysis indicated that the frequency of intermediate monocytes (AUC = 0.810, P |
| Databáze: | OpenAIRE |
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