Selective Cleavage of Cysteine Peptides
| Autor: | Toshishige Inui |
|---|---|
| Rok vydání: | 1971 |
| Předmět: | |
| Zdroj: | Bulletin of the Chemical Society of Japan. 44:2515-2520 |
| ISSN: | 1348-0634 0009-2673 |
| DOI: | 10.1246/bcsj.44.2515 |
| Popis: | The cysteine peptides such as IV were cyclized to thiazolidone peptides through the corresponding S-chlorocarbonyl derivatives. In some peptides such as XXII, however, no cyclized products were isolated because of decomposition of the S-chlorocarbonyl intermediates. By the mild alkaline hydrolysis of the thiazolidone peptide the carboxylic acid from the N-terminal amino acid or peptide and 2-oxothiazolidine-4-carbonyl derivatives were isolated as a result of the selective cleavage of the peptide bond in which an amino group of cysteine residue participated. This cleavage reaction was applied to several cysteine peptides. The same results were observed whenever the corresponding thiazolidone peptides were formed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|