Breaking the vicious cycle between tumor cell proliferation and bone resorption by chloroquine-loaded and bone-targeted polydopamine nanoparticles
| Autor: | Kaili Lin, Jianru Xiao, Quan Huang, Yiyun Cheng, Qiang Zhang, Ting Ying, Hui Chen, Xiaopan Cai, Yitong Wang |
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| Rok vydání: | 2020 |
| Předmět: |
Osteolysis
Materials science Autophagy 02 engineering and technology Photothermal therapy 010402 general chemistry 021001 nanoscience & nanotechnology medicine.disease 01 natural sciences Bone resorption 0104 chemical sciences Metastasis Cancer cell medicine Cancer research General Materials Science Tumor necrosis factor alpha 0210 nano-technology Receptor |
| Zdroj: | Science China Materials. 64:474-487 |
| ISSN: | 2199-4501 2095-8226 |
| Popis: | The vicious cycle between tumor cell proliferation and bone resorption remarkably elevates the progression and metastasis of bone tumors. Here, we fabricated polyethylene glycol-conjugated alendronate-functionalized and chloroquine (CQ)-loaded polydopamine nanoparticles (PPA/CQ) for efficient treatment of bone tumors via breaking the vicious cycle. The nanoparticles were efficiently accumulated to the bone tissues, especially the osteolytic lesions around tumors. CQ released from PPA/CQ inhibited osteoclastogenesis via preventing the degradation of tumor necrosis factor (TNF) receptor-associated receptor 3 to attenuate the osteolysis in bone tumors. On the other hand, CQ blocked the autophagy in cancer cells, resulting in improved photothermal killing of cancer cells. Finally, the in vivo experiment revealed that PPA/CQ-associated treatment efficiently inhibited both tumor growth and osteolysis. This work suggests that autophagy inhibition-associated photothermal therapy could be a promising strategy for treating malignant bone tumors. |
| Databáze: | OpenAIRE |
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