| Autor: |
Uttam Kumar Sarker, Fatiha Farhana, Md. Elias Molla, Mir Misbahuddin, Md. Rabiul Islam, Md. Mahasin Ali, Shifat Kaisar, Md. Atikul Islam |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Asian Journal of Pharmaceutical Research and Development. 8:14-17 |
| ISSN: |
2320-4850 |
| DOI: |
10.22270/ajprd.v8i3.717 |
| Popis: |
Objectives: The purpose of this study was to identify the impurities and their amounts in the fluconazole bulk drug and capsule FLUNACTM (150 mg). Method: HPLC with diode array detector was used to carry out the study. The composition of mobile phase was acetonitrile: water (85:15 %) with flow rate of 0.7 mL/min and detected at 260 ± 1 nm. Results: Two impurities (one is known impurity A and other unknown impurity) were detected in the bulk drug and also in capsule FLUNAC (150mg). The total amount of impurities in fluconazole bulk drug and capsule were 0.368% and 0.392% respectively. Conclusion: The total amount of impurities was less than 1% which is acceptable. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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