(Halogenomethyl)phenyl α-D-glucopyranosides as enzyme-activated irreversible inhibitors of yeast α-glucosidase and potential anti-HIV agents

Autor:	Josie C. Briggs, Alan H. Haines, Richard J. K. Taylor
Rok vydání:	1995
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Aglycone Enzyme Chemistry Anti hiv Stereochemistry α glucosidase Moiety Ring (chemistry) Yeast
Zdroj:	J. Chem. Soc., Perkin Trans. 1. :27-32
ISSN:	1364-5463 0300-922X
DOI:	10.1039/p19950000027
Popis:	A range of (halogenomethyl)phenyl α-D-glucopyranosides 2–7, prepared from corresponding methylphenyl glucosides by synthetic manipulation of the aglycone moiety, have been investigated as enzyme-activated irreversible inhibitors of yeast α-glucosidase and their anti-HIV activity measured. Compounds 5–7, which also contain a 4- or 6-nitro group in the phenyl ring of the aglycone, are much more effective inhibitors of the enzyme than are compounds 2–4 which lack this feature.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b9606e4501db43f8d1d82034be0b89a5 https://doi.org/10.1039/p19950000027 Zobrazit plný text záznamu