Analysis of Metoclopramide and Related Compounds in Tablets by Liquid Chromatography

Autor:	Gregory V. Williams, Aqeel A. Fatmi
Rok vydání:	1989
Předmět:	Pharmacology Chromatography Metoclopramide Hydrochloride Organic Chemistry Pharmaceutical Science Reversed-phase chromatography chemistry.chemical_compound chemistry Phase (matter) Drug Discovery Stability indicating medicine Methanol Acetonitrile Ammonium acetate medicine.drug
Zdroj:	Drug Development and Industrial Pharmacy. 15:1365-1373
ISSN:	1520-5762 0363-9045
DOI:	10.3109/03639048909062751
Popis:	A rapid, sensitive, stability indicating, reversed phase HPLC method for the quantitation of Metoclopramide and its related compounds is described. The sample is extracted in methanol and injected on a reverse phase CIS column with a mobile phase of 0.15M ammonium acetate and acetonitrile (80:20) with Wdetection at 268 nm. The method is highly specific, sensitive and has the ability to separate Metoclopramide from its related compunds; narnely, 4-acetylamino-5-chloro-N[2(diethylamino)ethyll-2-methoxybenzamide hydrochloride and 4-amino-5-chloro-2-methoxybenzoic acid in quantities of up to 10 ucg/mL. The method is highly reproducible with average assay recovery of 104.7 2 1.1%.
Databáze:	OpenAIRE
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