C77G mutation in protein tyrosine phosphatase gene and autoimmune hepatitis

Autor:	Babak Noorinayer, Fatemehsadat Esteghamat, Mohammad Hossein Sanati, Mohammadreza Agah, Hamid Mohaghegh Shalmani, Mohammad Reza Zali, Azita Hekmatdoost, Maryam Zafarghandi
Rok vydání:	2005
Předmět:	Genetics education.field_of_study Hepatology Population Heterozygote advantage Autoimmune hepatitis Biology medicine.disease law.invention Exon Infectious Diseases law Mutation (genetic algorithm) Genotype medicine education Genotyping Polymerase chain reaction
Zdroj:	Hepatology Research. 32:154-157
ISSN:	1386-6346
DOI:	10.1016/j.hepres.2005.04.006
Popis:	Autoimmune hepatitis (AIH) is a rare frequent, multiplex disorder with undefined etiology. Susceptibility to autoimmune hepatitis results from complex interactions between genetic and environmental factors. In this study, we investigated the involvement of C77G mutation in CD45 gene in patients with autoimmune hepatitis among Iranian population by genotyping this mutation in 70 patients and 140 healthy individuals. Methods: After amplifying exon 4 by Polymerase chain reaction, we genotyped this mutation with MspI restriction endonuclease among the studied population. Results: None of the cases with AIH was hetero or homozygote for C77G mutation. Controls had normal genotype except one of them who was heterozygote for C77G mutation. Conclusion: Our results do not confirm the genetic link between C77G mutation and autoimmune hepatitis in Iranian population.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::b956ab5ffa1404e9118923de8f8ec6fa https://doi.org/10.1016/j.hepres.2005.04.006 Zobrazit plný text záznamu